EXAMPLE QUESTIONS - copy & paste into the chatbot:
Can you write an introduction to my test SOP?
What properties of endotoxin make it such a concern to injectable drug manufacturers?
How do I write an endotoxin test standard operating procedure (SOP)?
What are the data integrity and documentation expectations in a laboratory setting?
How can I ensure compliance with CFR Part 11 in my laboratory processes?
What are the best practices for data storage and backup in a lab environment?
How do I determine if a compound, like ascorbic acid, requires endotoxin testing?
Is recombinant Factor C potentially better than LAL for endotoxin testing? USP <86> FAQS Approval
Endotoxin is said to be amphiphilic, what does that mean? Effects of charge
What is the pH requirement for the endotoxin test?
It is said that LPS occurs asymmetrically in the outer membrane of GNB, what is the significance of this?
In arthropods, did gills evolve into book gills in horseshoe crabs? Evo-Devo
What are interfering factors and how are they overcome?
How do you create the standard curve from the CSE?
Are horseshoe crabs endangered?
What is the domain structure of Factor C? See Fig. 1
Who developed LAL? Golden goose award
What are biological drugs?
What is TLR4? Structure
What was the early foundation for "germ theory"?
Is endotoxin a factor in sepsis?
What are PRR and PAMP pairs?
What is the difference between sterile and pyrogen-free?
What are PRR and PAMP pairs?
What are lipid A variants? Frontiers
What is the B cell structure and routine function?
What is the oldest continuous battle between eukaryotes and prokaryotes?
What is the timeline of the discovery of PRRs?
Is there a commonality between horseshoe crab blood proteins and human blood proteins? Complement
What is the relationship of porins to LPS molecules in the outer membrane of GNB? Complex architecture AFM
What are some different endotoxin aggregation states?
What is a method to determine non-product (e.g. raw material) specifications for an endotoxin control strategy?
What is the complement system? Complement
How do small molecule drugs (SMDs) differ from Biologics?
What is the future of endotoxin testing?
What is the PPC requirement?
What is an archive standard curve?
What is the issue of endotoxin-protein binding?
Are horseshoe crabs related to spiders?
If the endotoxin limit is <20 EU/mg and lambda is 0.05 EU/mL, what is the MVD?
If the drug dose is 50 mg/kg, what is the TL?
If the drug is an intrathecal and the dose is 0.1 mL/kg, what is the TL?
What if there are several different potencies of the same drug?
Is endotoxin an adjuvant? MPLA
What are the three cascade proteins in LAL? Factor C Factor B Proclotting enzyme
Who are the ancestors of horseshoe crabs?
What is the O-antigen part of endotoxin known for?
What are superantigens such as the toxins that cause toxic shock syndrome?
Why are non-endotoxin pyrogens of lesser concern in pharmaceutical manufacturing?
What is the monocyte activation test (MAT)?
What is a protostome versus a deuterostome?
Can you point me to a good picture of LPS?
